Exercise reduces metabolic burden while altering the immune system in aged mice

Although several evidence has suggested the impact of exercise on prevention aging phenotypes, few studies have been conducted mechanism by which alters immune-cell profile, thereby improving metabolism in senile obesity. In this study, we confirmed that 4-week treadmill sufficiently improved metabolic function, including increased lean mass and decreased fat mass, 88-week-old mice. The expression level senescence marker p16 white adipose tissue (WAT) was after 4-weeks exercise. Exercise induced changes profiles subsets, natural killer (NK) cells, central memory CD8+ T eosinophils, neutrophils, stromal vascular fraction WAT. addition, it shown through transcriptome analysis WAT can activate pathways involved interaction between immune particular NK aged These results suggest a profound effect distribution senescent-cell scavenging mice, eventually affecting overall energy toward more youthful state.